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1

Genetic effects on the commensal microbiota in inflammatory bowel disease patients

Aschard, Hugues, Laville, Vincent, Tchetgen, Eric Tchetgen, Knights, Dan, Imhann, Floris, Seksik, Philippe, Zaitlen, Noah, Silverberg, Mark S., Cosnes, Jacques, Weersma, Rinse K., Xavier, Ramnik, Beau

Journal:

Year:

2019

Language:

english

File:

PDF, 5.27 MB

english, 2019

2

Genetic effects on the commensal microbiota in inflammatory bowel disease patients

Aschard, Hugues, Laville, Vincent, Tchetgen, Eric Tchetgen, Knights, Dan, Imhann, Floris, Seksik, Philippe, Zaitlen, Noah, Silverberg, Mark S., Cosnes, Jacques, Weersma, Rinse K., Xavier, Ramnik, Beau

Journal:

Year:

2019

File:

PDF, 5.27 MB

2019

3

Inflated type I error rates when using aggregation methods to analyze rare variants in the 1000 Genomes Project exon sequencing data in unrelated individuals: summary results from Group 7 at Genetic Analysis Workshop 17

Nathan Tintle, Hugues Aschard, Inchi Hu, Nora Nock, Haitian Wang, Elizabeth Pugh

Journal:

Genetic Epidemiology

Year:

2011

Language:

english

File:

PDF, 85 KB

english, 2011

4

Combining effects from rare and common genetic variants in an exome-wide association study of sequence data

Hugues Aschard, Weiliang Qiu, Bogdan Pasaniuc, Noah Zaitlen, Michael H Cho, Vincent Carey

Journal:

BMC Proceedings

Year:

2011

Language:

english

File:

PDF, 207 KB

english, 2011

5

Sex-specific effect of IL9 polymorphisms on lung function and polysensitization

Kauffmann, F, Demenais, F, Aschard, H, Bouzigon, E, Corda, E, Ulgen, A, Dizier, M-H, Gormand, F, Lathrop, M

Journal:

Genes and Immunity

Year:

2009

Language:

english

File:

PDF, 130 KB

english, 2009

6

Inclusion of Gene-Gene and Gene-Environment Interactions Unlikely to Dramatically Improve Risk Prediction for Complex Diseases

Hugues Aschard, Jinbo Chen, Marilyn C. Cornelis, Lori B. Chibnik, Elizabeth W. Karlson, Peter Kraft

Journal:

The American Journal of Human Genetics

Year:

2012

Language:

english

File:

PDF, 797 KB

english, 2012

7

Inclusion of Gene-Gene and Gene-Environment Interactions Unlikely to Dramatically Improve Risk Prediction for Complex Diseases

Hugues Aschard, Jinbo Chen, Marilyn C. Cornelis, Lori B. Chibnik, Elizabeth W. Karlson, Peter Kraft

Journal:

The American Journal of Human Genetics

Year:

2012

Language:

english

File:

PDF, 28 KB

english, 2012

8

Transcriptional Response of Mucoid Pseudomonas aeruginosa to Human Respiratory Mucus

Cattoir, V., Narasimhan, G., Skurnik, D., Aschard, H., Roux, D., Ramphal, R., Jyot, J., Lory, S.

Journal:

Year:

2012

Language:

english

File:

PDF, 2.05 MB

english, 2012

9

Challenges and opportunities in genome-wide environmental interaction (GWEI) studies

Aschard, Hugues, Lutz, Sharon, Maus, Bärbel, Duell, Eric J., Fingerlin, Tasha E., Chatterjee, Nilanjan, Kraft, Peter, Steen, Kristel

Journal:

Year:

2012

Language:

english

File:

PDF, 421 KB

english, 2012

10

Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing

Skurnik, D., Roux, D., Cattoir, V., Danilchanka, O., Lu, X., Yoder-Himes, D. R., Han, K., Guillard, T., Jiang, D., Gaultier, C., Guerin, F., Aschard, H., Leclercq, R., Mekalanos, J. J., Lory, S., Pier

Journal:

Proceedings of the National Academy of Sciences

Year:

2013

Language:

english

File:

PDF, 1.10 MB

english, 2013

11

Effects of cholesterol-lowering with Simvastatin on stroke and other major vascular events in 20,536 people with cerebrovascular disease or other high-risk conditions

Aschard, Hugues, Vilhjálmsson, Bjarni J., Greliche, Nicolas, Morange, Pierre-Emmanuel, Trégouët, David-Alexandre, Kraft, Peter

Journal:

Journal of Vascular Surgery

Year:

2004

Language:

english

File:

PDF, 34 KB

english, 2004

12

Maximizing the Power of Principal-Component Analysis of Correlated Phenotypes in Genome-wide Association Studies

Aschard, Hugues, Vilhjálmsson, Bjarni J., Greliche, Nicolas, Morange, Pierre-Emmanuel, Trégouët, David-Alexandre, Kraft, Peter

Journal:

The American Journal of Human Genetics

Year:

2014

Language:

english

File:

PDF, 2.10 MB

english, 2014

13

Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study

Rudolph, A., Hein, R., Lindstrom, S., Beckmann, L., Behrens, S., Liu, J., Aschard, H., Bolla, M. K., Wang, J., Truong, T., Cordina-Duverger, E., Menegaux, F., Bruning, T., Harth, V., Severi, G., Bagli

Journal:

Endocrine Related Cancer

Year:

2013

Language:

english

File:

PDF, 267 KB

english, 2013

14

Effect of 17q21 Variants and Smoking Exposure in Early-Onset Asthma

Bouzigon, Emmanuelle, Corda, Eve, Aschard, Hugues, Dizier, Marie-Hélène, Boland, Anne, Bousquet, Jean, Chateigner, Nicolas, Gormand, Frédéric, Just, Jocelyne, Le Moual, Nicole, Scheinmann, Pierre, Sir

Journal:

Boston Medical and Surgical Journal

Year:

2008

Language:

english

File:

PDF, 254 KB

english, 2008

15

A Nonparametric Test to Detect Quantitative Trait Loci Where the Phenotypic Distribution Differs by Genotypes

Aschard, Hugues, Zaitlen, Noah, Tamimi, Rulla M., Lindström, Sara, Kraft, Peter

Journal:

Genetic Epidemiology

Year:

2013

Language:

english

File:

PDF, 866 KB

english, 2013

16

Adjusting for Heritable Covariates Can Bias Effect Estimates in Genome-Wide Association Studies

Aschard, Hugues, Vilhjálmsson, Bjarni J., Joshi, Amit D., Price, Alkes L., Kraft, Peter

Journal:

The American Journal of Human Genetics

Year:

2015

Language:

english

File:

PDF, 648 KB

english, 2015

17

Variation in Predictive Ability of Common Genetic Variants by Established Strata

Aschard, Hugues, Zaitlen, Noah, Lindström, Sara, Kraft, Peter

Journal:

Year:

2015

Language:

english

File:

PDF, 460 KB

english, 2015

18

Facteurs génétiques et environnementaux de l’asthme et de l’allergie : synthèse des résultats de l’étude EGEA

Bouzigon, E., Nadif, R., Le Moual, N., Dizier, M.-H., Aschard, H., Boudier, A., Bousquet, J., Chanoine, S., Donnay, C., Dumas, O., Gormand, F., Jacquemin, B., Just, J., Margaritte-Jeannin, P., Matran,

Journal:

Revue des Maladies Respiratoires

Year:

2015

Language:

french

File:

PDF, 1.90 MB

french, 2015

19

Finding the missing gene–environment interactions

Kraft, Peter, Aschard, Hugues

Journal:

European Journal of Epidemiology

Year:

2015

Language:

english

File:

PDF, 389 KB

english, 2015

20

17q21 variants modify the association between early respiratory infections and asthma

Smit, L. A. M., Bouzigon, E., Pin, I., Siroux, V., Monier, F., Aschard, H., Bousquet, J., Gormand, F., Just, J., Le Moual, N., Nadif, R., Scheinmann, P., Vervloet, D., Lathrop, M., Demenais, F., Kauff

Journal:

European Respiratory Journal

Year:

2010

Language:

english

File:

PDF, 336 KB

english, 2010

21

A Comprehensive Analysis of In Vitro and In Vivo Genetic Fitness of Pseudomonas aeruginosa Using High-Throughput Sequencing of Transposon Libraries

Skurnik, David, Roux, Damien, Aschard, Hugues, Cattoir, Vincent, Yoder-Himes, Deborah, Lory, Stephen, Pier, Gerald B., Kazmierczak, Barbara I.

Journal:

Year:

2013

Language:

english

File:

PDF, 3.82 MB

english, 2013

22

Fitness cost of antibiotic susceptibility during bacterial infection

Roux, D., Danilchanka, O., Guillard, T., Cattoir, V., Aschard, H., Fu, Y., Angoulvant, F., Messika, J., Ricard, J.-D., Mekalanos, J. J., Lory, S., Pier, G. B., Skurnik, D.

Journal:

Science Translational Medicine

Year:

2015

Language:

english

File:

PDF, 1.71 MB

english, 2015

23

Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma

Bailey, Jessica N Cooke, Loomis, Stephanie J, Kang, Jae H, Allingham, R Rand, Gharahkhani, Puya, Khor, Chiea Chuen, Burdon, Kathryn P, Aschard, Hugues, Chasman, Daniel I, Igo, Robert P, Hysi, Pirro G,

Journal:

Nature Genetics

Year:

2016

Language:

english

File:

PDF, 1.32 MB

english, 2016

24

Genome-Wide Meta-Analysis of Joint Tests for Genetic and Gene-Environment Interaction Effects

Aschard, Hugues, Hancock, Dana B., London, Stephanie J., Kraft, Peter

Journal:

Year:

2010

Language:

english

File:

PDF, 508 KB

english, 2010

25

Response to Day et al.

Aschard, Hugues, Vilhjálmsson, Bjarni J., Joshi, Amit D., Price, Alkes L., Kraft, Peter

Journal:

The American Journal of Human Genetics

Year:

2016

Language:

english

File:

PDF, 73 KB

english, 2016

26

Leveraging local ancestry to detect gene-gene interactions in genome-wide data

Aschard, Hugues, Gusev, Alexander, Brown, Robert, Pasaniuc, Bogdan

Journal:

Year:

2015

Language:

english

File:

PDF, 1.25 MB

english, 2015

27

An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group

Sung, Yun Ju, Winkler, Thomas W., Manning, Alisa K., Aschard, Hugues, Gudnason, Vilmundur, Harris, Tamara B., Smith, Albert V., Boerwinkle, Eric, Brown, Michael R., Morrison, Alanna C., Fornage, Myria

Journal:

Genetic Epidemiology

Year:

2016

Language:

english

File:

PDF, 1.30 MB

english, 2016

28

Genomics, Telomere Length, Epigenetics, and Metabolomics in the Nurses’ Health Studies

Townsend, Mary K., Aschard, Hugues, De Vivo, Immaculata, Michels, Karin B., Kraft, Peter

Journal:

American Journal of Public Health

Year:

2016

Language:

english

File:

PDF, 547 KB

english, 2016

29

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits

Teumer, Alexander, Qi, Qibin, Nethander, Maria, Aschard, Hugues, Bandinelli, Stefania, Beekman, Marian, Berndt, Sonja I., Bidlingmaier, Martin, Broer, Linda, Cappola, Anne, Ceda, Gian Paolo, Chanock,

Journal:

Year:

2016

Language:

english

File:

PDF, 822 KB

english, 2016

30

A perspective on interaction effects in genetic association studies

Aschard, Hugues

Journal:

Genetic Epidemiology

Year:

2016

Language:

english

File:

PDF, 993 KB

english, 2016

31

Pancreatic cancer risks associated with prediagnostic plasma levels of leptin and leptin receptor genetic polymorphisms

Babic, A., Bao, Y., Qian, Z. R., Yuan, C., Giovannucci, E. L., Aschard, H., Kraft, P., Amundadottir, L. T., Stolzenberg-Solomon, R. Z., Morales-Oyarvide, V., Ng, K., Stampfer, M. J., Ogino, S., Buring

Journal:

Cancer Research

Year:

2016

Language:

english

File:

PDF, 712 KB

english, 2016

32

Evidence for large-scale gene-by-smoking interaction effects on pulmonary function

Aschard, Hugues, Tobin, Martin D, Hancock, Dana B, Skurnik, David, Sood, Akshay, James, Alan, Vernon Smith, Albert, Manichaikul, Ani W, Campbell, Archie, Prins, Bram P, Hayward, Caroline, Loth, Daan W

Journal:

International Journal of Epidemiology

Year:

2017

Language:

english

File:

PDF, 636 KB

english, 2017

33

Update on the State of the Science for Analytical Methods for Gene-Environment Interactions (GxE)

Gauderman, W. James, Mukherjee, Bhramar, Aschard, Hugues, Hsu, Li, Lewinger, Juan Pablo, Patel, Chirag J., Witte, John S., Amos, Christopher, Tai, Caroline G., Conti, David, Torgerson, Dara G., Lee, S

Journal:

American Journal of Epidemiology

Year:

2017

Language:

english

File:

PDF, 911 KB

english, 2017

34

Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample

Pasquale, Louis R., Aschard, Hugues, Kang, Jae H., Bailey, Jessica N. Cooke, Lindström, Sara, Chasman, Daniel I., Christen, William G., Allingham, R. Rand, Ashley-Koch, Allison, Lee, Richard K., Moroi

Journal:

Year:

2017

Language:

english

File:

PDF, 210 KB

english, 2017

35

Incorporation of Biological Knowledge into the Study of Gene-Environment Interactions

Ritchie, Marylyn D., Davis, Joe R., Aschard, Hugues, Battle, Alexis, Conti, David, Du, Mengmeng, Eskin, Eleazar, Fallin, M. Daniele, Hsu, Li, Kraft, Peter, Moore, Jason H., Pierce, Brandon L., Bien, S

Journal:

American Journal of Epidemiology

Year:

2017

Language:

english

File:

PDF, 798 KB

english, 2017

36

Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis

Aschard, Hugues, Kang, Jae H, Iglesias, Adriana I, Hysi, Pirro, Cooke Bailey, Jessica N, Khawaja, Anthony P, Allingham, R Rand, Ashley-Koch, Allison, Lee, Richard K, Moroi, Sayoko E, Brilliant, Murray

Journal:

European Journal of Human Genetics

Year:

2017

Language:

english

File:

PDF, 715 KB

english, 2017

37

Covariate selection for association screening in multiphenotype genetic studies

Aschard, Hugues, Guillemot, Vincent, Vilhjalmsson, Bjarni, Patel, Chirag J, Skurnik, David, Ye, Chun J, Wolpin, Brian, Kraft, Peter, Zaitlen, Noah

Journal:

Nature Genetics

Year:

2017

Language:

english

File:

PDF, 3.21 MB

english, 2017

38

An ancestry-based approach for detecting interactions

Park, Danny S., Eskin, Itamar, Kang, Eun Yong, Gamazon, Eric R., Eng, Celeste, Gignoux, Christopher R., Galanter, Joshua M., Burchard, Esteban, Ye, Chun J., Aschard, Hugues, Eskin, Eleazar, Halperin,

Journal:

Genetic Epidemiology

Year:

2017

Language:

english

File:

PDF, 685 KB

english, 2017

39

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

Jiang, Xia, O’Reilly, Paul F., Aschard, Hugues, Hsu, Yi-Hsiang, Richards, J. Brent, Dupuis, Josée, Ingelsson, Erik, Karasik, David, Pilz, Stefan, Berry, Diane, Kestenbaum, Bryan, Zheng, Jusheng, Luan,

Journal:

Nature Communications

Year:

2018

Language:

english

File:

PDF, 1.13 MB

english, 2018

40

A test for gene-environment interaction in the presence of measurement error in the environmental variable

Aschard, Hugues, Spiegelman, Donna, Laville, Vincent, Kraft, Pete, Wang, Molin

Journal:

Genetic Epidemiology

Year:

2018

Language:

english

File:

PDF, 749 KB

english, 2018

41

Efficient analysis of large-scale genome-wide data with two R packages: bigstatsr and bigsnpr

Privé, Florian, Aschard, Hugues, Ziyatdinov, Andrey, Blum, Michael G B

Journal:

Year:

2017

Language:

english

File:

PDF, 2.31 MB

english, 2017

42

Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases

McAllister, Kimberly, Mechanic, Leah E., Amos, Christopher, Aschard, Hugues, Blair, Ian A., Chatterjee, Nilanjan, Conti, David, Gauderman, W. James, Hsu, Li, Hutter, Carolyn M., Jankowska, Marta M., K

Journal:

American Journal of Epidemiology

Year:

2017

Language:

english

File:

PDF, 160 KB

english, 2017

43

VarExp: Estimating variance explained by Genome-Wide GxE summary statistics

Laville, Vincent, Bentley, Amy R, Privé, Florian, Zhu, Xiaofeng, Gauderman, Jim, Winkler, Thomas W, Province, Mike, Rao, D C, Aschard, Hugues

Journal:

Year:

2018

Language:

english

File:

PDF, 227 KB

english, 2018

44

lme4qtl: linear mixed models with flexible covariance structure for genetic studies of related individuals

Ziyatdinov, Andrey, Vázquez-Santiago, Miquel, Brunel, Helena, Martinez-Perez, Angel, Aschard, Hugues, Soria, Jose Manuel

Journal:

BMC Bioinformatics

Year:

2018

Language:

english

File:

PDF, 359 KB

english, 2018

45

A two-step multiple-marker strategy for genome-wide association studies

Aschard, Hugues, Guedj, Mickaël, Demenais, Florence

Journal:

BMC Proceedings

Year:

2007

Language:

english

File:

PDF, 389 KB

english, 2007

46

Screening for interaction effects in gene expression data

Castaldi, Peter J., Cho, Michael H., Liang, Liming, Silverman, Edwin K., Hersh, Craig P., Rice, Kenneth, Aschard, Hugues, Brody, James P

Journal:

Year:

2017

Language:

english

File:

PDF, 2.64 MB

english, 2017

47

Exploring genome-wide – dietary heme iron intake interactions and the risk of type 2 diabetes

Pasquale, Louis R., Loomis, Stephanie J., Aschard, Hugues, Kang, Jae H., Cornelis, Marilyn C., Qi, Lu, Kraft, Peter, Hu, Frank B.

Journal:

Frontiers in Genetics

Year:

2013

Language:

english

File:

PDF, 274 KB

english, 2013

48

Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets

Bailey, Jessica N. Cooke, Gharahkhani, Puya, Kang, Jae H., Butkiewicz, Mariusz, Sullivan, David A., Weinreb, Robert N., Aschard, Hugues, Allingham, R. Rand, Ashley-Koch, Allison, Lee, Richard K., Moro

Journal:

Investigative Opthalmology & Visual Science

Year:

2018

File:

PDF, 390 KB

2018

49

Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets

Bailey, Jessica N. Cooke, Gharahkhani, Puya, Kang, Jae H., Butkiewicz, Mariusz, Sullivan, David A., Weinreb, Robert N., Aschard, Hugues, Allingham, R. Rand, Ashley-Koch, Allison, Lee, Richard K., Moro

Journal:

Investigative Opthalmology & Visual Science

Year:

2018

Language:

english

File:

PDF, 390 KB

english, 2018

50

Joint Analysis of Multiple Interaction Parameters in Genetic Association Studies

Kim, Jihye, Ziyatdinov, Andrey, Laville, Vincent, Hu, Frank B., Rimm, Eric, Kraft, Peter, Aschard, Hugues

Journal:

Year:

2018

Language:

english

File:

PDF, 1.98 MB

english, 2018

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